According to a recent study published in Trafficfollowing the American Heart Association’s Life’s Simple 7 (LS7) recommendations, is associated with a lower lifetime risk of developing coronary heart disease (CHD).
These recommendations have been developed with a focus on cardiovascular health factors that can be changed by lifestyle changes, such as encouraging people to quit smoking, adopt healthier diets, exercise regularly, maintain a healthy weight, control blood pressure and cholesterol, and lower blood levels. sugar levels.
Researchers reviewed data from the ARIC study of 10,686 patients aged 45 and older who had no coronary heart disease at baseline between 1987 and 1989: three follow-up studies were conducted between 2011-2013, 2016 -2017 and 2018-2019. 56% of patients were female and the median age was 54 years.
According to the researchers, many people are able to offset their lifetime risk of coronary heart disease by nearly half if they manage their health by adhering to LS7 recommendations. The results showed that the overall lifetime remaining risk of CAD was 27%, ranging from 16.6% in those with an ideal LS7 score to 43.1% in those with a poor score. Overall, similar estimates of lifetime risk were detected in all those with poor LS7 scores.
The association of polygenic risk score (PRS) with lifetime risk was found to differ depending on ancestry, for example in white patients the remaining lifetime risk ranged from 19.8% to 39.3 %, and black patients had a lifetime risk ranging from 19.1% to 28.6%, depending on increasing PRS categories.
“Our finding that high lifetime risk conferred by high SRP can be offset by a healthy lifestyle echoes the findings of previous studies that used more limited genetic risk scores and did not consider the concurrent risk of death,” wrote lead author Natalie R. Hasbani. , MPH, a specialist at the University of Texas Health Sciences Center at Houston, and colleagues.
The authors concluded that “ideal adherence to LS7 recommendations was associated with a lower lifetime risk of coronary heart disease for all individuals, particularly those with high genetic susceptibility. Among black participants, adherence to LS7 guidelines contributed more to lifetime risk of coronary heart disease than current PRS. Improved PRSs are needed to properly assess genetic susceptibility to CAD in diverse populations.
You can learn more about Life’s Simple 7 recommendations by clicking here.